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Our Research |
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Laser activated biological adhesivesThe use of biological sealants in laser welding has received attention due to the possible benefits in speed of application and healing. A range of adhesives are commonly used in a wide range of surgical procedures, from cyanoacrylate based glues for external use, to fibrinogen based adhesives used in conventional and laser assisted anastomosis. Here at Loughborough, in collaboration with Tissuemed Ltd, we have developed a totally biological-based light activated adhesive for use in a variety of environments. In addition to the protein base, the adhesive contains a visibly absorbing chromophore. When irradiated with a suitable light source, the light energy is absorbed by the chromophore and is converted to heat. The resultant temperature rise coagulates the protein substrate within the adhesive and forms "a weld" around the irradiated vessel. Selected References: “Methylene blue based protein solder for vascular anastomoses: an in vitro burst pressure study” J.F. Birch, D.J. Mandley, S.L. Williams, David R. Worrall, P.J. Trotter, F. Wilkinson and P.R. Bell, Lasers in Surgery and Medicine 2000, 26, 323-329.
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